Lupus medication (hydroxychloroquine, Benlysta, Saphnelo) cost in 2026
Lupus medication (hydroxychloroquine, Benlysta, Saphnelo) costs $13 to $5,664 per month in 2026, and most people pay about $2,839.
What moves the price
- Generic pills cost far less than brand name biologic drugs.
- Cash price, coupon price and insured price are all different.
- The form matters, such as a shot at home or an infusion at a clinic.
- The pharmacy or clinic changes the price.
- Insurance coverage and help programs change what a patient pays.
- Where you live. Prices in big cities usually run higher than in small towns.
What is included
Cash prices cover the drug only. Infusion drugs may also bring clinic fees, which are billed separately. Insurance often cuts what the patient pays a lot. Prices are for information only. Confirm costs and care with a licensed provider.
Lupus drug cash prices (about one month)
| Drug | Cash price as printed |
|---|---|
| Hydroxychloroquine 200 mg, 30 tablets | $13.16 to $17.57 |
| Hydroxychloroquine 200 mg, 60 tablets | $22.07 to $27.33 |
| Benlysta shot, 4 autoinjectors (200 mg/mL) | $5,231.87 (Drugs.com); $5,663.61 retail (GoodRx) |
| Benlysta 400 mg IV vial | $2,201.00 |
| Saphnelo 300 mg IV, 2 mL | $5,482.95 |
| Saphnelo 120 mg shot, 0.8 mL | $1,517.06 |
Average prices in US dollars. Source: Drugs.com.
Ways to pay less
- Compare coupon prices for generic pills at several pharmacies.
- Ask the drug maker about patient help programs for brand drugs.
- Ask the doctor and insurer which form of the drug costs less.
What price guides say
We checked 5 price guides and read every number on their pages. They do not all measure the same thing, so the ranges on this page come from putting them side by side.
Common questions
How much does this cost in 2026?
Lupus medication (hydroxychloroquine, Benlysta, Saphnelo) costs $13 to $5,664 per month in 2026, and most people pay about $2,839. Most people pay about $2,839 per month. The low end is $13 and the high end is $5,664.
What changes the price the most?
The biggest factors are: Generic pills cost far less than brand name biologic drugs; Cash price, coupon price and insured price are all different; The form matters, such as a shot at home or an infusion at a clinic.
How can I pay less?
Compare coupon prices for generic pills at several pharmacies. Ask the drug maker about patient help programs for brand drugs. Ask the doctor and insurer which form of the drug costs less.
Where do these numbers come from?
From 5 named price guides: Drugs.com, Drugs.com, Drugs.com, GoodRx, GoodRx. Each one is linked on this page with the date we read it.
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