Calquence cost in 2026
Calquence costs about $15,782 to $21,458 per month without insurance in 2026, at retail cash prices.
What moves the price
- The pack and strength. Prices here are for 60 tablets of 100 mg (one tablet twice a day, 30 days).
- Your coverage. Commercial insurance, Medicare and cash pay all get very different prices.
- The pharmacy. Cash prices for the same pack can differ by hundreds of dollars between stores.
- Whether a generic or biosimilar is on sale. No generic or biosimilar was found. Drugs.com lists only the brand.
What is included
The prices on this page are what a pharmacy charges for 60 tablets of 100 mg (one tablet twice a day, 30 days), before any insurance. Your own cost depends on your plan, your deductible and any savings card. Ask your pharmacist for the cash price and your insured price, and pay the lower one.
Ways to pay for Calquence
| How you pay | What it costs |
|---|---|
| Maker list price | $14,228 per month |
| Cash price without insurance | $15,782 to $21,458 per month (SingleCare (lowest price and typical retail price)) |
| With the maker's savings card | Calquence Patient Savings Program from AstraZeneca: commercially insured patients only, pay as little as $0 per 30 day supply, up to $26,000 a year in savings. |
| Medicare | Medicare negotiated price (maximum fair price) of $8,600 from Jan 1 2027 (announced Nov 25 2025); not on the 2026 list. |
| Free drug program | AstraZeneca's AZ&Me Prescription Savings Program may help people with limited income, including some on Medicare. Check the income rules on the AZ&Me website. |
| Generic or biosimilar | No generic or biosimilar was found. Drugs.com lists only the brand. |
Average prices in US dollars. Source: Manatt.
Ways to pay less
- Calquence Patient Savings Program from AstraZeneca: commercially insured patients only, pay as little as $0 per 30 day supply, up to $26,000 a year in savings.
- AstraZeneca's AZ&Me Prescription Savings Program may help people with limited income, including some on Medicare. Check the income rules on the AZ&Me website.
- Compare cash prices at several pharmacies with a free discount card before you pay.
- Ask your doctor if a generic or a lower cost drug would work for you.
What price guides say
We checked 6 price guides and read every number on their pages. They do not all measure the same thing, so the ranges on this page come from putting them side by side.
- Manatt: CMS Obtains Meaningful Discounts for IPAY 2027 Selected Drugs (2024 list price $14,228 for 30 days)
- Becker's Hospital Review: CMS to cut prices on 15 costly drugs in 2027
- SingleCare: Calquence Coupons & Prices
- Drugs.com: Calquence Prices, Coupons, Copay Cards & Patient Assistance
- GoodRx: Calquence page (savings program)
- PrescriberPoint: Calquence financial assistance
Common questions
How much does this cost in 2026?
Calquence costs about $15,782 to $21,458 per month without insurance in 2026, at retail cash prices. Most people pay about $18,620 per month. The low end is $15,782 and the high end is $21,458.
What changes the price the most?
The biggest factors are: The pack and strength. Prices here are for 60 tablets of 100 mg (one tablet twice a day, 30 days); Your coverage. Commercial insurance, Medicare and cash pay all get very different prices; The pharmacy. Cash prices for the same pack can differ by hundreds of dollars between stores.
How can I pay less?
Calquence Patient Savings Program from AstraZeneca: commercially insured patients only, pay as little as $0 per 30 day supply, up to $26,000 a year in savings. AstraZeneca's AZ&Me Prescription Savings Program may help people with limited income, including some on Medicare. Check the income rules on the AZ&Me website. Compare cash prices at several pharmacies with a free discount card before you pay.
Where do these numbers come from?
From 6 named price guides: Manatt, Becker's Hospital Review, SingleCare, Drugs.com, GoodRx, PrescriberPoint. Each one is linked on this page with the date we read it.
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