Entyvio cost in 2026
Entyvio costs about $6,993 to $9,689 per 2 pens (28 days) without insurance in 2026, at retail cash prices.
What moves the price
- The pack and strength. Prices here are for 2 prefilled pens of 108 mg/0.68 mL (one 28 day supply for the every 2 week pen dose); the IV form is one 300 mg vial per infusion.
- Your coverage. Commercial insurance, Medicare and cash pay all get very different prices.
- The pharmacy. Cash prices for the same pack can differ by hundreds of dollars between stores.
- Whether a generic or biosimilar is on sale. No. No vedolizumab biosimilar is approved in the US. Alvotech's AVT16 is under FDA review with a decision expected in Q1 2027.
What is included
The prices on this page are what a pharmacy charges for 2 prefilled pens of 108 mg/0.68 mL (one 28 day supply for the every 2 week pen dose); the IV form is one 300 mg vial per infusion, before any insurance. Your own cost depends on your plan, your deductible and any savings card. Ask your pharmacist for the cash price and your insured price, and pay the lower one.
Ways to pay for Entyvio
| How you pay | What it costs |
|---|---|
| Maker list price | $7,278 per 2 pens (28 days) |
| Cash price without insurance | $6,993 to $9,689 per 2 pens (28 days) (GoodRx) |
| With the maker's savings card | EntyvioConnect Co-Pay Program: commercially insured patients may pay as little as $0 per dose, up to $20,000 a year in benefit. Not valid with Medicare, Medicaid, TRICARE or other government coverage. |
| Medicare | Not on the 2026 or 2027 Medicare negotiation lists. Entyvio was selected for the 2028 list (prices effective Jan 1 2028); the negotiated price has not been announced yet. |
| Generic or biosimilar | No. No vedolizumab biosimilar is approved in the US. Alvotech's AVT16 is under FDA review with a decision expected in Q1 2027. |
Average prices in US dollars. Source: Takeda.
Ways to pay less
- EntyvioConnect Co-Pay Program: commercially insured patients may pay as little as $0 per dose, up to $20,000 a year in benefit. Not valid with Medicare, Medicaid, TRICARE or other government coverage.
- Compare cash prices at several pharmacies with a free discount card before you pay.
- Ask your doctor if a generic or a lower cost drug would work for you.
What price guides say
We checked 6 price guides and read every number on their pages. They do not all measure the same thing, so the ranges on this page come from putting them side by side.
Common questions
How much does this cost in 2026?
Entyvio costs about $6,993 to $9,689 per 2 pens (28 days) without insurance in 2026, at retail cash prices. Most people pay about $7,278 per 2 pens (28 days). The low end is $6,993 and the high end is $9,689.
What changes the price the most?
The biggest factors are: The pack and strength. Prices here are for 2 prefilled pens of 108 mg/0.68 mL (one 28 day supply for the every 2 week pen dose); the IV form is one 300 mg vial per infusion; Your coverage. Commercial insurance, Medicare and cash pay all get very different prices; The pharmacy. Cash prices for the same pack can differ by hundreds of dollars between stores.
How can I pay less?
EntyvioConnect Co-Pay Program: commercially insured patients may pay as little as $0 per dose, up to $20,000 a year in benefit. Not valid with Medicare, Medicaid, TRICARE or other government coverage. Compare cash prices at several pharmacies with a free discount card before you pay. Ask your doctor if a generic or a lower cost drug would work for you.
Where do these numbers come from?
From 6 named price guides: Takeda, Entyvio.com, GoodRx, Drugs.com, CMS, CMS. Each one is linked on this page with the date we read it.
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