Lybalvi cost in 2026
Lybalvi costs about $1,693 to $1,831 per month without insurance in 2026, at retail cash prices.
What moves the price
- The pack and strength. Prices here are for 30 tablets (olanzapine/samidorphan 5 mg/10 mg strength priced).
- Your coverage. Commercial insurance, Medicare and cash pay all get very different prices.
- The pharmacy. Cash prices for the same pack can differ by hundreds of dollars between stores.
- Whether a generic or biosimilar is on sale. No generic available; brand only.
What is included
The prices on this page are what a pharmacy charges for 30 tablets (olanzapine/samidorphan 5 mg/10 mg strength priced), before any insurance. Your own cost depends on your plan, your deductible and any savings card. Ask your pharmacist for the cash price and your insured price, and pay the lower one.
Ways to pay for Lybalvi
| How you pay | What it costs |
|---|---|
| Cash price without insurance | $1,693 to $1,831 per month (SingleCare) |
| With the maker's savings card | Lybalvi Co-pay Savings Program: eligible commercially insured patients may pay $0 for the first 3 fills, then $20 per 30-day supply, with maximum savings of $450 per 30-day fill. |
| Medicare | Lybalvi is not on the Medicare negotiation lists for 2026, 2027 or 2028. |
| Free drug program | Lybalvi Care Support is listed for uninsured patients with an FDA-approved diagnosis treated by a US-licensed provider; HealthWell Foundation copay program also listed. |
| Generic or biosimilar | No generic available; brand only. |
Average prices in US dollars. Source: Drugs.com.
Ways to pay less
- Lybalvi Co-pay Savings Program: eligible commercially insured patients may pay $0 for the first 3 fills, then $20 per 30-day supply, with maximum savings of $450 per 30-day fill.
- Lybalvi Care Support is listed for uninsured patients with an FDA-approved diagnosis treated by a US-licensed provider; HealthWell Foundation copay program also listed.
- Compare cash prices at several pharmacies with a free discount card before you pay.
- Ask your doctor if a generic or a lower cost drug would work for you.
What price guides say
We checked 5 price guides and read every number on their pages. They do not all measure the same thing, so the ranges on this page come from putting them side by side.
- Drugs.com: Lybalvi Prices, Coupons, Copay Cards & Patient Assistance
- SingleCare: Lybalvi Coupons & Prices
- CMS: Medicare Negotiation Selected Drug List IPAY 2028 factsheet
- AMCP: CMS Issues the List of Selected Drugs for Initial Price Applicability Year 2027
- Kiplinger: Here Are the 10 Medicare Negotiated Drug Prices
Common questions
How much does this cost in 2026?
Lybalvi costs about $1,693 to $1,831 per month without insurance in 2026, at retail cash prices. Most people pay about $1,762 per month. The low end is $1,693 and the high end is $1,831.
What changes the price the most?
The biggest factors are: The pack and strength. Prices here are for 30 tablets (olanzapine/samidorphan 5 mg/10 mg strength priced); Your coverage. Commercial insurance, Medicare and cash pay all get very different prices; The pharmacy. Cash prices for the same pack can differ by hundreds of dollars between stores.
How can I pay less?
Lybalvi Co-pay Savings Program: eligible commercially insured patients may pay $0 for the first 3 fills, then $20 per 30-day supply, with maximum savings of $450 per 30-day fill. Lybalvi Care Support is listed for uninsured patients with an FDA-approved diagnosis treated by a US-licensed provider; HealthWell Foundation copay program also listed. Compare cash prices at several pharmacies with a free discount card before you pay.
Where do these numbers come from?
From 5 named price guides: Drugs.com, SingleCare, CMS, AMCP, Kiplinger. Each one is linked on this page with the date we read it.
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