Opzelura cost in 2026
Opzelura costs about $1,837 to $2,839 per tube without insurance in 2026, at retail cash prices.
What moves the price
- The pack and strength. Prices here are for 60 g tube of 1.5% cream.
- Your coverage. Commercial insurance, Medicare and cash pay all get very different prices.
- The pharmacy. Cash prices for the same pack can differ by hundreds of dollars between stores.
- Whether a generic or biosimilar is on sale. Brand only. No generic available.
What is included
The prices on this page are what a pharmacy charges for 60 g tube of 1.5% cream, before any insurance. Your own cost depends on your plan, your deductible and any savings card. Ask your pharmacist for the cash price and your insured price, and pay the lower one.
Ways to pay for Opzelura
| How you pay | What it costs |
|---|---|
| Maker list price | $2,094 per tube |
| Cash price without insurance | $1,837 to $2,839 per tube (SingleCare (low coupon price and retail price); Drugs.com lists $2,094.34) |
| With the maker's savings card | Opzelura Copay Savings Program (833-613-2333): commercially insured patients may pay as little as $0 per tube; commercially insured or not covered patients may pay as little as $35 per tube. Limit one redemption per 25 days. |
| Medicare | Opzelura is not on the Medicare drug price negotiation lists for 2026, 2027 or 2028. |
| Free drug program | IncyteCARES for Opzelura (800-583-6964): for patients with no coverage, income at or below 400% of the federal poverty level, an FDA-approved diagnosis and US or Puerto Rico residence. |
| Generic or biosimilar | Brand only. No generic available. |
Average prices in US dollars. Source: Drugs.com.
Ways to pay less
- Opzelura Copay Savings Program (833-613-2333): commercially insured patients may pay as little as $0 per tube; commercially insured or not covered patients may pay as little as $35 per tube. Limit one redemption per 25 days.
- IncyteCARES for Opzelura (800-583-6964): for patients with no coverage, income at or below 400% of the federal poverty level, an FDA-approved diagnosis and US or Puerto Rico residence.
- Compare cash prices at several pharmacies with a free discount card before you pay.
- Ask your doctor if a generic or a lower cost drug would work for you.
What price guides say
We checked 5 price guides and read every number on their pages. They do not all measure the same thing, so the ranges on this page come from putting them side by side.
- Drugs.com: Opzelura Prices, Coupons, Copay Cards & Patient Assistance
- GoodRx: how much is opzelura cream without insurance
- SingleCare: opzelura without insurance
- CMS: Fact sheet, selected drug list for 2028
- AMCP: CMS Issues the List of Selected Drugs for Initial Price Applicability Year 2027
Common questions
How much does this cost in 2026?
Opzelura costs about $1,837 to $2,839 per tube without insurance in 2026, at retail cash prices. Most people pay about $2,094 per tube. The low end is $1,837 and the high end is $2,839.
What changes the price the most?
The biggest factors are: The pack and strength. Prices here are for 60 g tube of 1.5% cream; Your coverage. Commercial insurance, Medicare and cash pay all get very different prices; The pharmacy. Cash prices for the same pack can differ by hundreds of dollars between stores.
How can I pay less?
Opzelura Copay Savings Program (833-613-2333): commercially insured patients may pay as little as $0 per tube; commercially insured or not covered patients may pay as little as $35 per tube. Limit one redemption per 25 days. IncyteCARES for Opzelura (800-583-6964): for patients with no coverage, income at or below 400% of the federal poverty level, an FDA-approved diagnosis and US or Puerto Rico residence. Compare cash prices at several pharmacies with a free discount card before you pay.
Where do these numbers come from?
From 5 named price guides: Drugs.com, GoodRx, SingleCare, CMS, AMCP. Each one is linked on this page with the date we read it.
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