Xolair cost in 2026
Xolair costs about $2,991 to $3,991 per 300 mg syringe without insurance in 2026, at retail cash prices.
What moves the price
- The pack and strength. Prices here are for 1 prefilled syringe of 300 mg per 2 mL (monthly dose ranges from 75 mg to 600 mg, so some people need 2 syringes).
- Your coverage. Commercial insurance, Medicare and cash pay all get very different prices.
- The pharmacy. Cash prices for the same pack can differ by hundreds of dollars between stores.
- Whether a generic or biosimilar is on sale. Yes, a biosimilar is available: Celltrion's Omlyclo (omalizumab igec) launched in the US on October 5 2026, with no launch price published.
What is included
The prices on this page are what a pharmacy charges for 1 prefilled syringe of 300 mg per 2 mL (monthly dose ranges from 75 mg to 600 mg, so some people need 2 syringes), before any insurance. Your own cost depends on your plan, your deductible and any savings card. Ask your pharmacist for the cash price and your insured price, and pay the lower one.
Ways to pay for Xolair
| How you pay | What it costs |
|---|---|
| Maker list price | $2,946 per 300 mg syringe |
| Cash price without insurance | $2,991 to $3,991 per 300 mg syringe (SingleCare) |
| With the maker's savings card | Xolair Co-pay Program: for people with commercial insurance only (not Medicare, Medicaid, VA, TRICARE), age 18 or older. You may pay as little as $0, with up to $15,000 a year toward the drug and up to $1,500 a year toward the injection fee. |
| Medicare | Xolair is on the Medicare negotiation list for prices starting Jan 1 2028. The negotiated price has not been published yet; CMS must publish it by Nov 30 2026. Not on the 2026 or 2027 lists. |
| Generic or biosimilar | Yes, a biosimilar is available: Celltrion's Omlyclo (omalizumab igec) launched in the US on October 5 2026, with no launch price published. |
Average prices in US dollars. Source: Oregon Prescription Drug Affordability Board.
Ways to pay less
- Xolair Co-pay Program: for people with commercial insurance only (not Medicare, Medicaid, VA, TRICARE), age 18 or older. You may pay as little as $0, with up to $15,000 a year toward the drug and up to $1,500 a year toward the injection fee.
- Compare cash prices at several pharmacies with a free discount card before you pay.
- Ask your doctor if a generic or a lower cost drug would work for you.
What price guides say
We checked 6 price guides and read every number on their pages. They do not all measure the same thing, so the ranges on this page come from putting them side by side.
- Oregon Prescription Drug Affordability Board: Xolair 2026
- SingleCare: Xolair Coupons & Prices
- Drugs.com: Xolair Prices, Coupons, Copay Cards & Patient Assistance
- PrescriberPoint: Xolair Co-pay Program
- CMS: Fact sheet: Medicare negotiation selected drug list, initial price applicability year 2028
- CMS: Selected Drugs and Negotiated Prices
Common questions
How much does this cost in 2026?
Xolair costs about $2,991 to $3,991 per 300 mg syringe without insurance in 2026, at retail cash prices. Most people pay about $3,491 per 300 mg syringe. The low end is $2,991 and the high end is $3,991.
What changes the price the most?
The biggest factors are: The pack and strength. Prices here are for 1 prefilled syringe of 300 mg per 2 mL (monthly dose ranges from 75 mg to 600 mg, so some people need 2 syringes); Your coverage. Commercial insurance, Medicare and cash pay all get very different prices; The pharmacy. Cash prices for the same pack can differ by hundreds of dollars between stores.
How can I pay less?
Xolair Co-pay Program: for people with commercial insurance only (not Medicare, Medicaid, VA, TRICARE), age 18 or older. You may pay as little as $0, with up to $15,000 a year toward the drug and up to $1,500 a year toward the injection fee. Compare cash prices at several pharmacies with a free discount card before you pay. Ask your doctor if a generic or a lower cost drug would work for you.
Where do these numbers come from?
From 6 named price guides: Oregon Prescription Drug Affordability Board, SingleCare, Drugs.com, PrescriberPoint, CMS, CMS. Each one is linked on this page with the date we read it.
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